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Preventing the Progression of Diabetic Kidney Disease

Received: 5 February 2014     Published: 20 March 2014
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Abstract

Diabetic kidney disease (DKD) is a progressive condition and is an important cause of end-stage renal disease (ESRD) causing increased morbidity and mortality. The objective of this review article is to discuss about recognition and treatment of early DKD to prevent its progression. Informations have been gathered from related clinical studies, research works, articles, abstracts, and guidelines of different organizations published in various journals. Microalbuminuria describes the urinary excretion of small amounts of albumin which identifies the early stage of DKD. In addition to an earliest marker of kidney damage, microalbuminuria is an established high risk factor for cardiovascular morbidity and mortality. Patients with microalbuminuria who progress to macroalbuminuria are likely to progress to ESRD. There is general agreement that people with diabetes should be screened regularly to detect early markers of kidney damage. Albumin creatinine ratio in a morning urine sample is the preferred method of detecting microalbuminuria in diabetes. There is strong evidence that a number of interventions if initiated at early stage of DKD reduces the risk and slows the progression of kidney damage. People with diabetes and microalbuminuria should be treated with a multifactorial intervention approach to retard the progression of DKD. Studies have clearly demonstrated that the use of angiotensin converting enzyme inhibitors or angiotensin 2 receptor blockers with improved glycemic control, blood pressure control, lipid lowering, aspirin, smoking cessation, exercise programs and dietary intervention reduced the development of overt nephropathy and ESRD.

Published in American Journal of Internal Medicine (Volume 2, Issue 2)
DOI 10.11648/j.ajim.20140202.14
Page(s) 26-33
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Diabetic Kidney Disease, Macroalbuminuria, Microalbuminuria

References
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Cite This Article
  • APA Style

    Sheikh Salahuddin Ahmed. (2014). Preventing the Progression of Diabetic Kidney Disease. American Journal of Internal Medicine, 2(2), 26-33. https://doi.org/10.11648/j.ajim.20140202.14

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    ACS Style

    Sheikh Salahuddin Ahmed. Preventing the Progression of Diabetic Kidney Disease. Am. J. Intern. Med. 2014, 2(2), 26-33. doi: 10.11648/j.ajim.20140202.14

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    AMA Style

    Sheikh Salahuddin Ahmed. Preventing the Progression of Diabetic Kidney Disease. Am J Intern Med. 2014;2(2):26-33. doi: 10.11648/j.ajim.20140202.14

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  • @article{10.11648/j.ajim.20140202.14,
      author = {Sheikh Salahuddin Ahmed},
      title = {Preventing the Progression of Diabetic Kidney Disease},
      journal = {American Journal of Internal Medicine},
      volume = {2},
      number = {2},
      pages = {26-33},
      doi = {10.11648/j.ajim.20140202.14},
      url = {https://doi.org/10.11648/j.ajim.20140202.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20140202.14},
      abstract = {Diabetic kidney disease (DKD) is a progressive condition and is an important cause of end-stage renal disease (ESRD) causing increased morbidity and mortality. The objective of this review article is to discuss about recognition and treatment of early DKD to prevent its progression. Informations have been gathered from related clinical studies, research works, articles, abstracts, and guidelines of different organizations published in various journals. Microalbuminuria describes the urinary excretion of small amounts of albumin which identifies the early stage of DKD. In addition to an earliest marker of kidney damage, microalbuminuria is an established high risk factor for cardiovascular morbidity and mortality. Patients with microalbuminuria who progress to macroalbuminuria are likely to progress to ESRD. There is general agreement that people with diabetes should be screened regularly to detect early markers of kidney damage. Albumin creatinine ratio in a morning urine sample is the preferred method of detecting microalbuminuria in diabetes. There is strong evidence that a number of interventions if initiated at early stage of DKD reduces the risk and slows the progression of kidney damage. People with diabetes and microalbuminuria should be treated with a multifactorial intervention approach to retard the progression of DKD. Studies have clearly demonstrated that the use of angiotensin converting enzyme inhibitors or angiotensin 2 receptor blockers with improved glycemic control, blood pressure control, lipid lowering, aspirin, smoking cessation, exercise programs and dietary intervention reduced the development of overt nephropathy and ESRD.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Preventing the Progression of Diabetic Kidney Disease
    AU  - Sheikh Salahuddin Ahmed
    Y1  - 2014/03/20
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajim.20140202.14
    DO  - 10.11648/j.ajim.20140202.14
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 26
    EP  - 33
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20140202.14
    AB  - Diabetic kidney disease (DKD) is a progressive condition and is an important cause of end-stage renal disease (ESRD) causing increased morbidity and mortality. The objective of this review article is to discuss about recognition and treatment of early DKD to prevent its progression. Informations have been gathered from related clinical studies, research works, articles, abstracts, and guidelines of different organizations published in various journals. Microalbuminuria describes the urinary excretion of small amounts of albumin which identifies the early stage of DKD. In addition to an earliest marker of kidney damage, microalbuminuria is an established high risk factor for cardiovascular morbidity and mortality. Patients with microalbuminuria who progress to macroalbuminuria are likely to progress to ESRD. There is general agreement that people with diabetes should be screened regularly to detect early markers of kidney damage. Albumin creatinine ratio in a morning urine sample is the preferred method of detecting microalbuminuria in diabetes. There is strong evidence that a number of interventions if initiated at early stage of DKD reduces the risk and slows the progression of kidney damage. People with diabetes and microalbuminuria should be treated with a multifactorial intervention approach to retard the progression of DKD. Studies have clearly demonstrated that the use of angiotensin converting enzyme inhibitors or angiotensin 2 receptor blockers with improved glycemic control, blood pressure control, lipid lowering, aspirin, smoking cessation, exercise programs and dietary intervention reduced the development of overt nephropathy and ESRD.
    VL  - 2
    IS  - 2
    ER  - 

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Author Information
  • Department of Internal medicine, Bangladesh Institute of Health Sciences (BIHS), Dhaka, Bangladesh

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