Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives

Simone Parisi; Marco Scarati; Marta Priora; Clara Lisa Peroni; Angela Laganà; Enrico Fusaro

doi:doi:10.11648/j.ajim.20150305.12

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Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives

Simone Parisi, Marco Scarati, Marta Priora, Clara Lisa Peroni, Angela Laganà, Enrico Fusaro

Published in American Journal of Internal Medicine (Volume 3, Issue 5)

Received: 3 August 2015 Accepted: 10 August 2015 Published: 19 August 2015

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Abstract

Objective: The aim of this study was to assess the efficacy (in terms of improved VAS Pain, Raynaud's Phenomenon attacks frequency and Raynaud’s Condition Score) of the Aminaftone in patients with Raynaud’s Phenomenon (RP) secondary to Systemic Sclerosis (SSc). Methods: Open label controlled study. We evaluated the efficacy of Aminaftone in the treatment of secondary RP in 108 patients with SSc consecutively recruited and divided in two groups. Group A: 51 Patients in treatment with Calcium Channel Blockers, prostanoids (iloprost 2ng [min/kg every 4 weeks), Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors (Standard of Care). Group B: 57 Patients in treatment with Calcium Channel Blockers, Prostanoids, Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors and Aminaftone (Standard of care + Aminaftone). Results: The number of RP attacks in group treated with Aminaftone (Group B) was lower than the group treated with standard therapy (Group A) from baseline to Week 48, obtaining statistically significance (Δ A -1.50 Δ B -2.10 p=0.02 95%CI). The RCS was statistically significantly different (Δ A -1.60 Δ B -2.50 p=0,04 95% CI), as was the pain VAS(Δ A -20.80 Δ B -30.60 p=0.04 95%CI) at week 48. Conclusion: The use of Aminaftone was well tolerated and improved RP as measured by RCS and pain when added to standard of care. A well-designed randomized controlled trial is needed to determine if these preliminary findings are supported

Published in	American Journal of Internal Medicine (Volume 3, Issue 5)
DOI	10.11648/j.ajim.20150305.12
Page(s)	204-209
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Raynaud’s Phenomenon, Systemic Sclerosis, Aminaftone, Endotheline

References

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APA Style

Simone Parisi, Marco Scarati, Marta Priora, Clara Lisa Peroni, Angela Laganà, et al. (2015). Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives. American Journal of Internal Medicine, 3(5), 204-209. https://doi.org/10.11648/j.ajim.20150305.12

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ACS Style

Simone Parisi; Marco Scarati; Marta Priora; Clara Lisa Peroni; Angela Laganà, et al. Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives. Am. J. Intern. Med. 2015, 3(5), 204-209. doi: 10.11648/j.ajim.20150305.12

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AMA Style

Simone Parisi, Marco Scarati, Marta Priora, Clara Lisa Peroni, Angela Laganà, et al. Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives. Am J Intern Med. 2015;3(5):204-209. doi: 10.11648/j.ajim.20150305.12

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@article{10.11648/j.ajim.20150305.12,
  author = {Simone Parisi and Marco Scarati and Marta Priora and Clara Lisa Peroni and Angela Laganà and Enrico Fusaro},
  title = {Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives},
  journal = {American Journal of Internal Medicine},
  volume = {3},
  number = {5},
  pages = {204-209},
  doi = {10.11648/j.ajim.20150305.12},
  url = {https://doi.org/10.11648/j.ajim.20150305.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150305.12},
  abstract = {Objective: The aim of this study was to assess the efficacy (in terms of improved VAS Pain, Raynaud's Phenomenon attacks frequency and Raynaud’s Condition Score) of the Aminaftone in patients with Raynaud’s Phenomenon (RP) secondary to Systemic Sclerosis (SSc). Methods: Open label controlled study. We evaluated the efficacy of Aminaftone in the treatment of secondary RP in 108 patients with SSc consecutively recruited and divided in two groups. Group A: 51 Patients in treatment with Calcium Channel Blockers, prostanoids (iloprost 2ng [min/kg every 4 weeks), Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors (Standard of Care). Group B: 57 Patients in treatment with Calcium Channel Blockers, Prostanoids, Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors and Aminaftone (Standard of care + Aminaftone). Results: The number of RP attacks in group treated with Aminaftone (Group B) was lower than the group treated with standard therapy (Group A) from baseline to Week 48, obtaining statistically significance (Δ A -1.50 Δ B -2.10 p=0.02 95%CI). The RCS was statistically significantly different (Δ A -1.60 Δ B -2.50 p=0,04 95% CI), as was the pain VAS(Δ A -20.80 Δ B -30.60 p=0.04 95%CI) at week 48. Conclusion: The use of Aminaftone was well tolerated and improved RP as measured by RCS and pain when added to standard of care. A well-designed randomized controlled trial is needed to determine if these preliminary findings are supported},
 year = {2015}
}

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TY  - JOUR
T1  - Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives
AU  - Simone Parisi
AU  - Marco Scarati
AU  - Marta Priora
AU  - Clara Lisa Peroni
AU  - Angela Laganà
AU  - Enrico Fusaro
Y1  - 2015/08/19
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.20150305.12
DO  - 10.11648/j.ajim.20150305.12
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 204
EP  - 209
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20150305.12
AB  - Objective: The aim of this study was to assess the efficacy (in terms of improved VAS Pain, Raynaud's Phenomenon attacks frequency and Raynaud’s Condition Score) of the Aminaftone in patients with Raynaud’s Phenomenon (RP) secondary to Systemic Sclerosis (SSc). Methods: Open label controlled study. We evaluated the efficacy of Aminaftone in the treatment of secondary RP in 108 patients with SSc consecutively recruited and divided in two groups. Group A: 51 Patients in treatment with Calcium Channel Blockers, prostanoids (iloprost 2ng [min/kg every 4 weeks), Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors (Standard of Care). Group B: 57 Patients in treatment with Calcium Channel Blockers, Prostanoids, Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors and Aminaftone (Standard of care + Aminaftone). Results: The number of RP attacks in group treated with Aminaftone (Group B) was lower than the group treated with standard therapy (Group A) from baseline to Week 48, obtaining statistically significance (Δ A -1.50 Δ B -2.10 p=0.02 95%CI). The RCS was statistically significantly different (Δ A -1.60 Δ B -2.50 p=0,04 95% CI), as was the pain VAS(Δ A -20.80 Δ B -30.60 p=0.04 95%CI) at week 48. Conclusion: The use of Aminaftone was well tolerated and improved RP as measured by RCS and pain when added to standard of care. A well-designed randomized controlled trial is needed to determine if these preliminary findings are supported
VL  - 3
IS  - 5
ER  -

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Author Information

Simone Parisi

Department of General and Specialist Medicine, Division of Rheumatology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy
Marco Scarati

Department of General and Specialist Medicine, Division of Rheumatology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy
Marta Priora

Department of General and Specialist Medicine, Division of Rheumatology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy
Clara Lisa Peroni

Department of General and Specialist Medicine, Division of Rheumatology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy
Angela Laganà

Department of General and Specialist Medicine, Division of Rheumatology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy
Enrico Fusaro

Department of General and Specialist Medicine, Division of Rheumatology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy

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APA Style

Simone Parisi, Marco Scarati, Marta Priora, Clara Lisa Peroni, Angela Laganà, et al. (2015). Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives. American Journal of Internal Medicine, 3(5), 204-209. https://doi.org/10.11648/j.ajim.20150305.12

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ACS Style

Simone Parisi; Marco Scarati; Marta Priora; Clara Lisa Peroni; Angela Laganà, et al. Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives. Am. J. Intern. Med. 2015, 3(5), 204-209. doi: 10.11648/j.ajim.20150305.12

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AMA Style

Simone Parisi, Marco Scarati, Marta Priora, Clara Lisa Peroni, Angela Laganà, et al. Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives. Am J Intern Med. 2015;3(5):204-209. doi: 10.11648/j.ajim.20150305.12

Copy | Download

@article{10.11648/j.ajim.20150305.12,
  author = {Simone Parisi and Marco Scarati and Marta Priora and Clara Lisa Peroni and Angela Laganà and Enrico Fusaro},
  title = {Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives},
  journal = {American Journal of Internal Medicine},
  volume = {3},
  number = {5},
  pages = {204-209},
  doi = {10.11648/j.ajim.20150305.12},
  url = {https://doi.org/10.11648/j.ajim.20150305.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150305.12},
  abstract = {Objective: The aim of this study was to assess the efficacy (in terms of improved VAS Pain, Raynaud's Phenomenon attacks frequency and Raynaud’s Condition Score) of the Aminaftone in patients with Raynaud’s Phenomenon (RP) secondary to Systemic Sclerosis (SSc). Methods: Open label controlled study. We evaluated the efficacy of Aminaftone in the treatment of secondary RP in 108 patients with SSc consecutively recruited and divided in two groups. Group A: 51 Patients in treatment with Calcium Channel Blockers, prostanoids (iloprost 2ng [min/kg every 4 weeks), Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors (Standard of Care). Group B: 57 Patients in treatment with Calcium Channel Blockers, Prostanoids, Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors and Aminaftone (Standard of care + Aminaftone). Results: The number of RP attacks in group treated with Aminaftone (Group B) was lower than the group treated with standard therapy (Group A) from baseline to Week 48, obtaining statistically significance (Δ A -1.50 Δ B -2.10 p=0.02 95%CI). The RCS was statistically significantly different (Δ A -1.60 Δ B -2.50 p=0,04 95% CI), as was the pain VAS(Δ A -20.80 Δ B -30.60 p=0.04 95%CI) at week 48. Conclusion: The use of Aminaftone was well tolerated and improved RP as measured by RCS and pain when added to standard of care. A well-designed randomized controlled trial is needed to determine if these preliminary findings are supported},
 year = {2015}
}

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TY  - JOUR
T1  - Aminaftone in the Treatment of Raynaud’s Phenomenon in Systemic Sclerosis: New Perspectives
AU  - Simone Parisi
AU  - Marco Scarati
AU  - Marta Priora
AU  - Clara Lisa Peroni
AU  - Angela Laganà
AU  - Enrico Fusaro
Y1  - 2015/08/19
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.20150305.12
DO  - 10.11648/j.ajim.20150305.12
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 204
EP  - 209
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20150305.12
AB  - Objective: The aim of this study was to assess the efficacy (in terms of improved VAS Pain, Raynaud's Phenomenon attacks frequency and Raynaud’s Condition Score) of the Aminaftone in patients with Raynaud’s Phenomenon (RP) secondary to Systemic Sclerosis (SSc). Methods: Open label controlled study. We evaluated the efficacy of Aminaftone in the treatment of secondary RP in 108 patients with SSc consecutively recruited and divided in two groups. Group A: 51 Patients in treatment with Calcium Channel Blockers, prostanoids (iloprost 2ng [min/kg every 4 weeks), Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors (Standard of Care). Group B: 57 Patients in treatment with Calcium Channel Blockers, Prostanoids, Endothelin Receptor Antagonist and Phosphodiesterase-5 inhibitors and Aminaftone (Standard of care + Aminaftone). Results: The number of RP attacks in group treated with Aminaftone (Group B) was lower than the group treated with standard therapy (Group A) from baseline to Week 48, obtaining statistically significance (Δ A -1.50 Δ B -2.10 p=0.02 95%CI). The RCS was statistically significantly different (Δ A -1.60 Δ B -2.50 p=0,04 95% CI), as was the pain VAS(Δ A -20.80 Δ B -30.60 p=0.04 95%CI) at week 48. Conclusion: The use of Aminaftone was well tolerated and improved RP as measured by RCS and pain when added to standard of care. A well-designed randomized controlled trial is needed to determine if these preliminary findings are supported
VL  - 3
IS  - 5
ER  -

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