Background/Aim of the study: Osteoporosis and osteopenia are well known complications in patients with chronic liver disease, we aimed to investigate Egyptian male patients with chronic hepatitis C infection as regard the bone mineral density and risk factors for osteoporosis in this subpopulation and correlating it to BMI (body mass index). Patients and methods: One Hundred ninety-three Egyptian male patients with hepatitis C virus CLD has been enrolled and consented: 116 under weight and 77 normal weight, Chronic HCV infection was confirmed by positive anti-HCV antibodies and HCV RNA PCR. Cirrhosis was diagnosed based on sonographic and laboratory criteria. Noninvasive methods were used: the FibroScan test was used for assessment of liver fibrosis. Blood was drawn for routine tests included total serum calcium, phosphate, creatinine and total alkaline phosphatase using standard methods. 25-hydroxy vitamin D (25OHD) were done. Bone mineral density: BMD of the lumbar spine, femoral neck: using dual energy x-ray absorptiometry (DEXA)Scan were analyzed by the same technician. Results were correlated to Body mass index and Serum vitamin D level. Results: Demographic Data and Clinical Characteristics of Under and Normal Weight Chronic Hepatitis C Men were recorded, the results showed statistically significant correlations between under and normal weight HCV patients regarding BMI and BMD (in right hip and femoral neck, p values were 0.002 and 0.004, respectively). Subnormal 25 hydroxy vitamin D levels were present in 64% of the underweight patients and 51% of the normal weight patients with no significant differences between both groups. Conclusion: the body weight and BMI might be more detrimental for low BMD in male patients with CLD secondary to HCV infection rather than vitamin D status.
| Published in | American Journal of Internal Medicine (Volume 3, Issue 5) |
| DOI | 10.11648/j.ajim.20150305.14 |
| Page(s) | 213-216 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Chronic Hepatitis C, Low Vitamin D Level, Underweight, Bone Mineral Density
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APA Style
Amin R. Soliman, Hatem Darwish, Ahmed Hamdy, Mahmoud A. Soliman. (2015). Underweight May Be a Risk Factor for Lower Bone Density in Chronic Hepatitis C Infected Male Patients. American Journal of Internal Medicine, 3(5), 213-216. https://doi.org/10.11648/j.ajim.20150305.14
ACS Style
Amin R. Soliman; Hatem Darwish; Ahmed Hamdy; Mahmoud A. Soliman. Underweight May Be a Risk Factor for Lower Bone Density in Chronic Hepatitis C Infected Male Patients. Am. J. Intern. Med. 2015, 3(5), 213-216. doi: 10.11648/j.ajim.20150305.14
AMA Style
Amin R. Soliman, Hatem Darwish, Ahmed Hamdy, Mahmoud A. Soliman. Underweight May Be a Risk Factor for Lower Bone Density in Chronic Hepatitis C Infected Male Patients. Am J Intern Med. 2015;3(5):213-216. doi: 10.11648/j.ajim.20150305.14
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Download@article{10.11648/j.ajim.20150305.14,
author = {Amin R. Soliman and Hatem Darwish and Ahmed Hamdy and Mahmoud A. Soliman},
title = {Underweight May Be a Risk Factor for Lower Bone Density in Chronic Hepatitis C Infected Male Patients},
journal = {American Journal of Internal Medicine},
volume = {3},
number = {5},
pages = {213-216},
doi = {10.11648/j.ajim.20150305.14},
url = {https://doi.org/10.11648/j.ajim.20150305.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150305.14},
abstract = {Background/Aim of the study: Osteoporosis and osteopenia are well known complications in patients with chronic liver disease, we aimed to investigate Egyptian male patients with chronic hepatitis C infection as regard the bone mineral density and risk factors for osteoporosis in this subpopulation and correlating it to BMI (body mass index). Patients and methods: One Hundred ninety-three Egyptian male patients with hepatitis C virus CLD has been enrolled and consented: 116 under weight and 77 normal weight, Chronic HCV infection was confirmed by positive anti-HCV antibodies and HCV RNA PCR. Cirrhosis was diagnosed based on sonographic and laboratory criteria. Noninvasive methods were used: the FibroScan test was used for assessment of liver fibrosis. Blood was drawn for routine tests included total serum calcium, phosphate, creatinine and total alkaline phosphatase using standard methods. 25-hydroxy vitamin D (25OHD) were done. Bone mineral density: BMD of the lumbar spine, femoral neck: using dual energy x-ray absorptiometry (DEXA)Scan were analyzed by the same technician. Results were correlated to Body mass index and Serum vitamin D level. Results: Demographic Data and Clinical Characteristics of Under and Normal Weight Chronic Hepatitis C Men were recorded, the results showed statistically significant correlations between under and normal weight HCV patients regarding BMI and BMD (in right hip and femoral neck, p values were 0.002 and 0.004, respectively). Subnormal 25 hydroxy vitamin D levels were present in 64% of the underweight patients and 51% of the normal weight patients with no significant differences between both groups. Conclusion: the body weight and BMI might be more detrimental for low BMD in male patients with CLD secondary to HCV infection rather than vitamin D status.},
year = {2015}
}
TY - JOUR T1 - Underweight May Be a Risk Factor for Lower Bone Density in Chronic Hepatitis C Infected Male Patients AU - Amin R. Soliman AU - Hatem Darwish AU - Ahmed Hamdy AU - Mahmoud A. Soliman Y1 - 2015/09/09 PY - 2015 N1 - https://doi.org/10.11648/j.ajim.20150305.14 DO - 10.11648/j.ajim.20150305.14 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 213 EP - 216 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20150305.14 AB - Background/Aim of the study: Osteoporosis and osteopenia are well known complications in patients with chronic liver disease, we aimed to investigate Egyptian male patients with chronic hepatitis C infection as regard the bone mineral density and risk factors for osteoporosis in this subpopulation and correlating it to BMI (body mass index). Patients and methods: One Hundred ninety-three Egyptian male patients with hepatitis C virus CLD has been enrolled and consented: 116 under weight and 77 normal weight, Chronic HCV infection was confirmed by positive anti-HCV antibodies and HCV RNA PCR. Cirrhosis was diagnosed based on sonographic and laboratory criteria. Noninvasive methods were used: the FibroScan test was used for assessment of liver fibrosis. Blood was drawn for routine tests included total serum calcium, phosphate, creatinine and total alkaline phosphatase using standard methods. 25-hydroxy vitamin D (25OHD) were done. Bone mineral density: BMD of the lumbar spine, femoral neck: using dual energy x-ray absorptiometry (DEXA)Scan were analyzed by the same technician. Results were correlated to Body mass index and Serum vitamin D level. Results: Demographic Data and Clinical Characteristics of Under and Normal Weight Chronic Hepatitis C Men were recorded, the results showed statistically significant correlations between under and normal weight HCV patients regarding BMI and BMD (in right hip and femoral neck, p values were 0.002 and 0.004, respectively). Subnormal 25 hydroxy vitamin D levels were present in 64% of the underweight patients and 51% of the normal weight patients with no significant differences between both groups. Conclusion: the body weight and BMI might be more detrimental for low BMD in male patients with CLD secondary to HCV infection rather than vitamin D status. VL - 3 IS - 5 ER -
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