Mapsin  Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma

Sahar Mohamed El-Sheikh; Amani Noureldin Abd El-Latif

doi:doi:10.11648/j.ajls.20140203.18

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Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma

Sahar Mohamed El-Sheikh, Amani Noureldin Abd El-Latif

Published in American Journal of Life Sciences (Volume 2, Issue 3)

Received: 9 June 2014 Accepted: 13 June 2014 Published: 30 June 2014

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Abstract

Salivary gland tumors comprise a significant proportion of oral tumors. Maspin is a non-inhibitory serine protease inhibitor (serpin). It is supposed to suppress tumor-induced angiogenesis, tumor cell motility, invasion and metastasis. Objectives: To evaluate salivary gland tumors clinically, investigate the immunoexpression of maspin in mucoepidermoid and adenocystic carcinoma of the salivary gland tumors and to detect the correlation of maspin expression with biological behavior of these tumors.Materials and methods: Fourteen cases of malignant salivary gland tumors were retrieved from the Oral Pathology files of Faculty of Dentistry, Alexandria University, Egypt. The study included eight cases of mucoepidermoid carcinoma, six cases of adenoid cystic carcinoma. Two specimens of normal salivary tissue were taken as control.Results: The difference in mean optical density of maspin expression between low-grade and high-grade MEC was calculated. Optical density was higher in low-grade type compared to the high grade one with a significant difference (P< 0.05).Moreover, the results of this study showed difference between the MOD of adenoid cystic carcinoma subtypes, with the solid subtype expressing the lowest percentage. Conclusion: Maspin protein is overexpressed in low grade malignant salivary gland tumors, and decrease as the histological malignancy rises so it can be used as prognostic marker in salivary gland carcinoma. In addition, maspin could serve as a therapeutic target in salivary gland tumors including recombinant protein or gene therapy.

Published in	American Journal of Life Sciences (Volume 2, Issue 3)
DOI	10.11648/j.ajls.20140203.18
Page(s)	182-189
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Mucoepidermoid Carcinoma, Adenoid Cystic Carcinoma, Maspin

References

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Sahar Mohamed El-Sheikh, Amani Noureldin Abd El-Latif. (2014). Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma. American Journal of Life Sciences, 2(3), 182-189. https://doi.org/10.11648/j.ajls.20140203.18

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ACS Style

Sahar Mohamed El-Sheikh; Amani Noureldin Abd El-Latif. Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma. Am. J. Life Sci. 2014, 2(3), 182-189. doi: 10.11648/j.ajls.20140203.18

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AMA Style

Sahar Mohamed El-Sheikh, Amani Noureldin Abd El-Latif. Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma. Am J Life Sci. 2014;2(3):182-189. doi: 10.11648/j.ajls.20140203.18

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@article{10.11648/j.ajls.20140203.18,
  author = {Sahar Mohamed El-Sheikh and Amani Noureldin Abd El-Latif},
  title = {Mapsin  Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {3},
  pages = {182-189},
  doi = {10.11648/j.ajls.20140203.18},
  url = {https://doi.org/10.11648/j.ajls.20140203.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140203.18},
  abstract = {Salivary gland tumors comprise a significant proportion of oral tumors. Maspin is a non-inhibitory serine protease inhibitor (serpin). It is supposed to suppress tumor-induced angiogenesis, tumor cell motility, invasion and metastasis. Objectives: To evaluate salivary gland tumors clinically, investigate the immunoexpression of maspin in mucoepidermoid and adenocystic carcinoma of the salivary gland tumors and to detect the correlation of maspin expression with biological behavior of these tumors.Materials and methods: Fourteen cases of malignant salivary gland tumors were retrieved from the Oral Pathology files of Faculty of Dentistry, Alexandria University, Egypt. The study included eight cases of mucoepidermoid carcinoma, six cases of adenoid cystic carcinoma. Two specimens of normal salivary tissue were taken as control.Results: The difference in mean optical density of maspin expression between low-grade and high-grade MEC was calculated. Optical density was higher in low-grade type compared to the high grade one with a significant difference (P< 0.05).Moreover, the results of this study showed difference between the MOD of adenoid cystic carcinoma subtypes, with the solid subtype expressing the lowest percentage. Conclusion: Maspin protein is overexpressed in low grade malignant salivary gland tumors, and decrease as the histological malignancy rises so it can be used as prognostic marker in salivary gland carcinoma. In addition, maspin could serve as a therapeutic target in salivary gland tumors including recombinant protein or gene therapy.},
 year = {2014}
}

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TY  - JOUR
T1  - Mapsin  Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma
AU  - Sahar Mohamed El-Sheikh
AU  - Amani Noureldin Abd El-Latif
Y1  - 2014/06/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajls.20140203.18
DO  - 10.11648/j.ajls.20140203.18
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 182
EP  - 189
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140203.18
AB  - Salivary gland tumors comprise a significant proportion of oral tumors. Maspin is a non-inhibitory serine protease inhibitor (serpin). It is supposed to suppress tumor-induced angiogenesis, tumor cell motility, invasion and metastasis. Objectives: To evaluate salivary gland tumors clinically, investigate the immunoexpression of maspin in mucoepidermoid and adenocystic carcinoma of the salivary gland tumors and to detect the correlation of maspin expression with biological behavior of these tumors.Materials and methods: Fourteen cases of malignant salivary gland tumors were retrieved from the Oral Pathology files of Faculty of Dentistry, Alexandria University, Egypt. The study included eight cases of mucoepidermoid carcinoma, six cases of adenoid cystic carcinoma. Two specimens of normal salivary tissue were taken as control.Results: The difference in mean optical density of maspin expression between low-grade and high-grade MEC was calculated. Optical density was higher in low-grade type compared to the high grade one with a significant difference (P< 0.05).Moreover, the results of this study showed difference between the MOD of adenoid cystic carcinoma subtypes, with the solid subtype expressing the lowest percentage. Conclusion: Maspin protein is overexpressed in low grade malignant salivary gland tumors, and decrease as the histological malignancy rises so it can be used as prognostic marker in salivary gland carcinoma. In addition, maspin could serve as a therapeutic target in salivary gland tumors including recombinant protein or gene therapy.
VL  - 2
IS  - 3
ER  -

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Author Information

Sahar Mohamed El-Sheikh

Professor of oral pathology, Faculty of dentistry, Alexandria University, Egypt
Amani Noureldin Abd El-Latif

Associatte professor of oral pathology, Faculty of dentistry, Pharos University, Alexandria, Egypt

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APA Style

Sahar Mohamed El-Sheikh, Amani Noureldin Abd El-Latif. (2014). Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma. American Journal of Life Sciences, 2(3), 182-189. https://doi.org/10.11648/j.ajls.20140203.18

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ACS Style

Sahar Mohamed El-Sheikh; Amani Noureldin Abd El-Latif. Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma. Am. J. Life Sci. 2014, 2(3), 182-189. doi: 10.11648/j.ajls.20140203.18

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AMA Style

Sahar Mohamed El-Sheikh, Amani Noureldin Abd El-Latif. Mapsin Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma. Am J Life Sci. 2014;2(3):182-189. doi: 10.11648/j.ajls.20140203.18

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@article{10.11648/j.ajls.20140203.18,
  author = {Sahar Mohamed El-Sheikh and Amani Noureldin Abd El-Latif},
  title = {Mapsin  Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {3},
  pages = {182-189},
  doi = {10.11648/j.ajls.20140203.18},
  url = {https://doi.org/10.11648/j.ajls.20140203.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140203.18},
  abstract = {Salivary gland tumors comprise a significant proportion of oral tumors. Maspin is a non-inhibitory serine protease inhibitor (serpin). It is supposed to suppress tumor-induced angiogenesis, tumor cell motility, invasion and metastasis. Objectives: To evaluate salivary gland tumors clinically, investigate the immunoexpression of maspin in mucoepidermoid and adenocystic carcinoma of the salivary gland tumors and to detect the correlation of maspin expression with biological behavior of these tumors.Materials and methods: Fourteen cases of malignant salivary gland tumors were retrieved from the Oral Pathology files of Faculty of Dentistry, Alexandria University, Egypt. The study included eight cases of mucoepidermoid carcinoma, six cases of adenoid cystic carcinoma. Two specimens of normal salivary tissue were taken as control.Results: The difference in mean optical density of maspin expression between low-grade and high-grade MEC was calculated. Optical density was higher in low-grade type compared to the high grade one with a significant difference (P< 0.05).Moreover, the results of this study showed difference between the MOD of adenoid cystic carcinoma subtypes, with the solid subtype expressing the lowest percentage. Conclusion: Maspin protein is overexpressed in low grade malignant salivary gland tumors, and decrease as the histological malignancy rises so it can be used as prognostic marker in salivary gland carcinoma. In addition, maspin could serve as a therapeutic target in salivary gland tumors including recombinant protein or gene therapy.},
 year = {2014}
}

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TY  - JOUR
T1  - Mapsin  Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma
AU  - Sahar Mohamed El-Sheikh
AU  - Amani Noureldin Abd El-Latif
Y1  - 2014/06/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajls.20140203.18
DO  - 10.11648/j.ajls.20140203.18
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 182
EP  - 189
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140203.18
AB  - Salivary gland tumors comprise a significant proportion of oral tumors. Maspin is a non-inhibitory serine protease inhibitor (serpin). It is supposed to suppress tumor-induced angiogenesis, tumor cell motility, invasion and metastasis. Objectives: To evaluate salivary gland tumors clinically, investigate the immunoexpression of maspin in mucoepidermoid and adenocystic carcinoma of the salivary gland tumors and to detect the correlation of maspin expression with biological behavior of these tumors.Materials and methods: Fourteen cases of malignant salivary gland tumors were retrieved from the Oral Pathology files of Faculty of Dentistry, Alexandria University, Egypt. The study included eight cases of mucoepidermoid carcinoma, six cases of adenoid cystic carcinoma. Two specimens of normal salivary tissue were taken as control.Results: The difference in mean optical density of maspin expression between low-grade and high-grade MEC was calculated. Optical density was higher in low-grade type compared to the high grade one with a significant difference (P< 0.05).Moreover, the results of this study showed difference between the MOD of adenoid cystic carcinoma subtypes, with the solid subtype expressing the lowest percentage. Conclusion: Maspin protein is overexpressed in low grade malignant salivary gland tumors, and decrease as the histological malignancy rises so it can be used as prognostic marker in salivary gland carcinoma. In addition, maspin could serve as a therapeutic target in salivary gland tumors including recombinant protein or gene therapy.
VL  - 2
IS  - 3
ER  -

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