Objective: The primary objective of this study was to assess the efficacy of Quetiapine versus Aripiprazol in treating non-affective acute psychosis. Methods: This study is double blind, randomized-controlled clinical trial (RCT). A total number of 90 hospitalized patients with the diagnosis of acute psychosis were selected. The patients were treated with Quetiapine (mean: 500 mg/day) or Aripiprazol (mean: 20 mg/day), in a 4 weeks period. The positive and negative symptoms scale (PANSS) and clinical global impression severity scale (CGIS-s) were used in the first and the last day of trial. Results: This study reveals that both of these drugs can substantially reduce the severity of symptoms in acute psychosis. Aripiprazol reduced positive symptoms and general symptoms scores and total scores more than Quetiapine. Differences in reducing negative scores were not significant and both drugs had the same therapeutic effect. In this sense, there was no difference in reducing negative symptoms in acute psychosis between Aripiprazol and Quetiapine. Conclusion: According to some differences with similar studies, study on larger sample pool and in longer period in future researches can be advised.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 5, Issue 1) |
| DOI | 10.11648/j.ajpn.20170501.12 |
| Page(s) | 6-9 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Antipsychotics, Aripiprazol, Quetiapine, Non-affective Acute Psychosis
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APA Style
S. Mohamad Moosavi, Mahshid Ahmadi, Mani B. Monajemi. (2017). Aripiprazol Versus Quetiapine in Treatment of Non-affective Acute Psychosis: A Double-Blind, Randomized - Controlled Clinical Trial. American Journal of Psychiatry and Neuroscience, 5(1), 6-9. https://doi.org/10.11648/j.ajpn.20170501.12
ACS Style
S. Mohamad Moosavi; Mahshid Ahmadi; Mani B. Monajemi. Aripiprazol Versus Quetiapine in Treatment of Non-affective Acute Psychosis: A Double-Blind, Randomized - Controlled Clinical Trial. Am. J. Psychiatry Neurosci. 2017, 5(1), 6-9. doi: 10.11648/j.ajpn.20170501.12
AMA Style
S. Mohamad Moosavi, Mahshid Ahmadi, Mani B. Monajemi. Aripiprazol Versus Quetiapine in Treatment of Non-affective Acute Psychosis: A Double-Blind, Randomized - Controlled Clinical Trial. Am J Psychiatry Neurosci. 2017;5(1):6-9. doi: 10.11648/j.ajpn.20170501.12
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Download@article{10.11648/j.ajpn.20170501.12,
author = {S. Mohamad Moosavi and Mahshid Ahmadi and Mani B. Monajemi},
title = {Aripiprazol Versus Quetiapine in Treatment of Non-affective Acute Psychosis: A Double-Blind, Randomized - Controlled Clinical Trial},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {5},
number = {1},
pages = {6-9},
doi = {10.11648/j.ajpn.20170501.12},
url = {https://doi.org/10.11648/j.ajpn.20170501.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20170501.12},
abstract = {Objective: The primary objective of this study was to assess the efficacy of Quetiapine versus Aripiprazol in treating non-affective acute psychosis. Methods: This study is double blind, randomized-controlled clinical trial (RCT). A total number of 90 hospitalized patients with the diagnosis of acute psychosis were selected. The patients were treated with Quetiapine (mean: 500 mg/day) or Aripiprazol (mean: 20 mg/day), in a 4 weeks period. The positive and negative symptoms scale (PANSS) and clinical global impression severity scale (CGIS-s) were used in the first and the last day of trial. Results: This study reveals that both of these drugs can substantially reduce the severity of symptoms in acute psychosis. Aripiprazol reduced positive symptoms and general symptoms scores and total scores more than Quetiapine. Differences in reducing negative scores were not significant and both drugs had the same therapeutic effect. In this sense, there was no difference in reducing negative symptoms in acute psychosis between Aripiprazol and Quetiapine. Conclusion: According to some differences with similar studies, study on larger sample pool and in longer period in future researches can be advised.},
year = {2017}
}
TY - JOUR T1 - Aripiprazol Versus Quetiapine in Treatment of Non-affective Acute Psychosis: A Double-Blind, Randomized - Controlled Clinical Trial AU - S. Mohamad Moosavi AU - Mahshid Ahmadi AU - Mani B. Monajemi Y1 - 2017/02/21 PY - 2017 N1 - https://doi.org/10.11648/j.ajpn.20170501.12 DO - 10.11648/j.ajpn.20170501.12 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 6 EP - 9 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.20170501.12 AB - Objective: The primary objective of this study was to assess the efficacy of Quetiapine versus Aripiprazol in treating non-affective acute psychosis. Methods: This study is double blind, randomized-controlled clinical trial (RCT). A total number of 90 hospitalized patients with the diagnosis of acute psychosis were selected. The patients were treated with Quetiapine (mean: 500 mg/day) or Aripiprazol (mean: 20 mg/day), in a 4 weeks period. The positive and negative symptoms scale (PANSS) and clinical global impression severity scale (CGIS-s) were used in the first and the last day of trial. Results: This study reveals that both of these drugs can substantially reduce the severity of symptoms in acute psychosis. Aripiprazol reduced positive symptoms and general symptoms scores and total scores more than Quetiapine. Differences in reducing negative scores were not significant and both drugs had the same therapeutic effect. In this sense, there was no difference in reducing negative symptoms in acute psychosis between Aripiprazol and Quetiapine. Conclusion: According to some differences with similar studies, study on larger sample pool and in longer period in future researches can be advised. VL - 5 IS - 1 ER -
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