Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia

Nagwa Gad Mohamed; Shamina Begum; Mohamed Hamed El-Batanony; Sawsan Mohammed Al Blewi; Walaa Mahmood; Mohammad Zubair

doi:doi:10.11648/j.ejpm.20160401.11

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Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia

Nagwa Gad Mohamed, Shamina Begum, Mohamed Hamed El-Batanony, Sawsan Mohammed Al Blewi, Walaa Mahmood, Mohammad Zubair

Published in European Journal of Preventive Medicine (Volume 4, Issue 1)

Received: 7 December 2015 Accepted: 21 December 2015 Published: 4 January 2016

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Abstract

Neonatal sepsis is defined as a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 28 days of life. Of newborns with early-onset sepsis, 85% present within 24 hours, 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. The present study included 38 septic neonates. They were divided into two groups: Group with early onset neonatal sepsis (29) and another group with late onset neonatal sepsis (9). The study group with early-onset sepsis showed 18 (62.1%) males, 11 (37.9%) females, mean gestational age (weeks) 34.28±4.7, mean body weight (gm) 2.1±0.8, mean Apgar score at 1 min. 6.7±1.8. 21 (72.4%) delivered by CS, 8 (27.6%) delivered by NVD. E. coli was the commonest organism identified in blood culture of septic neonates. Maternal anemia, PROM, and fever were significant risk factors for neonatal sepsis. Prematurity and low birth weights were among the most common neonatal risk factors. Respiratory manifestations were the commonest manifestations of neonatal sepsis in both groups. Treating maternal anemia during pregnancy will help to reduce the incidence of neonatal sepsis E. coli is still an important cause of early-onset neonatal sepsis. Blood cultures need to be done strictly before the start of the first dose of antibiotic.

Published in	European Journal of Preventive Medicine (Volume 4, Issue 1)
DOI	10.11648/j.ejpm.20160401.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Neonatal Sepsis, Bacteriological Profile, Tabuk, Kingdom of Saudi Arabia

References

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[2]	Baltimore A. (2002): Perinatal bacterial and fungal infections. In: Hal B. Jenson and Robert S. Baltimore, editors. Pediatric infectious diseases principles and practice. Philadelphia; 96: 1119-33.
[3]	Bang AT, Baitule SB, Reddy HM. (1999): Effect of home-based neonatal care and management of sepsis on neonatal mortality: field trial in rural Indian. Lancet; 354: 1955-61.
[4]	Betty C and Inderpreet S. (1997): Early onset neonatal sepsis. The Indian Ped; (72): p. 23-26.
[5]	Chacko et al (2005): Early onset neonatal sepsis. J Indian pediatr; 17: 538-543.
[6]	Ehl S, Gehring B, pohlandtF. (2005): A detailed analysis of changes of serum CRP levels in neonates treated for bacterial infections Eur J pediatr; 158: 238-42.
[7]	Hodge D, Puntis JWL. (2004): Diagnosis, preventing, and management of catheter related œ bloodstream infection during long-term parenteral nutrition. Arch Dis Child Fetal Neonatal J; 87: 21.
[8]	Kirkwood BR, Sterne JAC (2003): essential medical statistics, 2nd ed. Oxford: Blackwell scientific.
[9]	Klein JO, Marcy SM (1999): Bacterial sepsis and meningitis. Infectious Diseaes of the Fetus and Newborn, Philadelphia WB Saunders. Klein JO, Remington JS. (2001): Current concepts of infections of the Disease of the fetus and Newborn Infant. 5th ed. Philadelphia, WB fetus and newborn infant, Remington JS, Klein JO (editors): Infectious Saunders; 1-23.
[10]	Mc Pherson RJ, Juul, Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. J. perinatol 2005; 25: 166-72.
[11]	Mohammad Karambin, MD* and Marjaneh Zarkesh, MD. Entrobacter, the Most Common Pathogen of Neonatal Septicemia in Rasht, Iran. Iran J Pediatr. 2011 Mar; 21 (1): 83–87.
[12]	Orlikwsky TW, Neunhoeffer F, Goelz R. (2004): Evaluation of IL 8 concentrations in plasma and lysed EDTA-blood in healthy neonates and those with suspected early onset bacterial infection. Pediatr Res; 56: 804-9.
[13]	Polin R. (2003): The ins and outs of neonatal sepsis. J Pediatr; 143: 3-4.
[14]	Stephen F, Kingsmore, Henry L, Halliday. (2008): Identification of Diagnostic Biomarkers for Infection in Premature Neonates, National Center for Genome Resources, Santa Fe, New Mexico, Molecular & Cellular Proteomics; 7: 1863-1875.

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Nagwa Gad Mohamed, Shamina Begum, Mohamed Hamed El-Batanony, Sawsan Mohammed Al Blewi, Walaa Mahmood, et al. (2016). Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia. European Journal of Preventive Medicine, 4(1), 1-6. https://doi.org/10.11648/j.ejpm.20160401.11

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ACS Style

Nagwa Gad Mohamed; Shamina Begum; Mohamed Hamed El-Batanony; Sawsan Mohammed Al Blewi; Walaa Mahmood, et al. Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia. Eur. J. Prev. Med. 2016, 4(1), 1-6. doi: 10.11648/j.ejpm.20160401.11

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AMA Style

Nagwa Gad Mohamed, Shamina Begum, Mohamed Hamed El-Batanony, Sawsan Mohammed Al Blewi, Walaa Mahmood, et al. Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia. Eur J Prev Med. 2016;4(1):1-6. doi: 10.11648/j.ejpm.20160401.11

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@article{10.11648/j.ejpm.20160401.11,
  author = {Nagwa Gad Mohamed and Shamina Begum and Mohamed Hamed El-Batanony and Sawsan Mohammed Al Blewi and Walaa Mahmood and Mohammad Zubair},
  title = {Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia},
  journal = {European Journal of Preventive Medicine},
  volume = {4},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.ejpm.20160401.11},
  url = {https://doi.org/10.11648/j.ejpm.20160401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20160401.11},
  abstract = {Neonatal sepsis is defined as a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 28 days of life. Of newborns with early-onset sepsis, 85% present within 24 hours, 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. The present study included 38 septic neonates. They were divided into two groups: Group with early onset neonatal sepsis (29) and another group with late onset neonatal sepsis (9). The study group with early-onset sepsis showed 18 (62.1%) males, 11 (37.9%) females, mean gestational age (weeks) 34.28±4.7, mean body weight (gm) 2.1±0.8, mean Apgar score at 1 min. 6.7±1.8. 21 (72.4%) delivered by CS, 8 (27.6%) delivered by NVD. E. coli was the commonest organism identified in blood culture of septic neonates. Maternal anemia, PROM, and fever were significant risk factors for neonatal sepsis. Prematurity and low birth weights were among the most common neonatal risk factors. Respiratory manifestations were the commonest manifestations of neonatal sepsis in both groups. Treating maternal anemia during pregnancy will help to reduce the incidence of neonatal sepsis E. coli is still an important cause of early-onset neonatal sepsis. Blood cultures need to be done strictly before the start of the first dose of antibiotic.},
 year = {2016}
}

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TY - JOUR
T1 - Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia
AU - Nagwa Gad Mohamed
AU - Shamina Begum
AU - Mohamed Hamed El-Batanony
AU - Sawsan Mohammed Al Blewi
AU - Walaa Mahmood
AU - Mohammad Zubair
Y1 - 2016/01/04
PY - 2016
N1 - https://doi.org/10.11648/j.ejpm.20160401.11
DO - 10.11648/j.ejpm.20160401.11
T2 - European Journal of Preventive Medicine
JF - European Journal of Preventive Medicine
JO - European Journal of Preventive Medicine
SP - 1
EP - 6
PB - Science Publishing Group
SN - 2330-8230
UR - https://doi.org/10.11648/j.ejpm.20160401.11
AB - Neonatal sepsis is defined as a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 28 days of life. Of newborns with early-onset sepsis, 85% present within 24 hours, 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. The present study included 38 septic neonates. They were divided into two groups: Group with early onset neonatal sepsis (29) and another group with late onset neonatal sepsis (9). The study group with early-onset sepsis showed 18 (62.1%) males, 11 (37.9%) females, mean gestational age (weeks) 34.28±4.7, mean body weight (gm) 2.1±0.8, mean Apgar score at 1 min. 6.7±1.8. 21 (72.4%) delivered by CS, 8 (27.6%) delivered by NVD. E. coli was the commonest organism identified in blood culture of septic neonates. Maternal anemia, PROM, and fever were significant risk factors for neonatal sepsis. Prematurity and low birth weights were among the most common neonatal risk factors. Respiratory manifestations were the commonest manifestations of neonatal sepsis in both groups. Treating maternal anemia during pregnancy will help to reduce the incidence of neonatal sepsis E. coli is still an important cause of early-onset neonatal sepsis. Blood cultures need to be done strictly before the start of the first dose of antibiotic.
VL - 4
IS - 1
ER -

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Author Information

Nagwa Gad Mohamed

Department of Paediatrics, Faculty of Medicine, Ministry of Higher Education, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Shamina Begum

Department of Medical Microbiology Faculty of Medicine, Ministry of Higher Education, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Mohamed Hamed El-Batanony

King Khaled Hospital, Ministry of Health Tabuk, Tabuk, Kingdom of Saudi Arabia
Sawsan Mohammed Al Blewi

Department of Paediatrics, Faculty of Medicine, Ministry of Higher Education, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Walaa Mahmood

Department of Family Medicine, Faculty of Medicine, Ministry of Higher Education, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Mohammad Zubair

Department of Medical Microbiology Faculty of Medicine, Ministry of Higher Education, University of Tabuk, Tabuk, Kingdom of Saudi Arabia

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APA Style

Nagwa Gad Mohamed, Shamina Begum, Mohamed Hamed El-Batanony, Sawsan Mohammed Al Blewi, Walaa Mahmood, et al. (2016). Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia. European Journal of Preventive Medicine, 4(1), 1-6. https://doi.org/10.11648/j.ejpm.20160401.11

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ACS Style

Nagwa Gad Mohamed; Shamina Begum; Mohamed Hamed El-Batanony; Sawsan Mohammed Al Blewi; Walaa Mahmood, et al. Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia. Eur. J. Prev. Med. 2016, 4(1), 1-6. doi: 10.11648/j.ejpm.20160401.11

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AMA Style

Nagwa Gad Mohamed, Shamina Begum, Mohamed Hamed El-Batanony, Sawsan Mohammed Al Blewi, Walaa Mahmood, et al. Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia. Eur J Prev Med. 2016;4(1):1-6. doi: 10.11648/j.ejpm.20160401.11

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@article{10.11648/j.ejpm.20160401.11,
  author = {Nagwa Gad Mohamed and Shamina Begum and Mohamed Hamed El-Batanony and Sawsan Mohammed Al Blewi and Walaa Mahmood and Mohammad Zubair},
  title = {Clinical and Bacteriological Profile of Neonatal Sepsis in King Khaleed Civilian Hospital, Tabuk, Kingdom of Saudi Arabia},
  journal = {European Journal of Preventive Medicine},
  volume = {4},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.ejpm.20160401.11},
  url = {https://doi.org/10.11648/j.ejpm.20160401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20160401.11},
  abstract = {Neonatal sepsis is defined as a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 28 days of life. Of newborns with early-onset sepsis, 85% present within 24 hours, 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. The present study included 38 septic neonates. They were divided into two groups: Group with early onset neonatal sepsis (29) and another group with late onset neonatal sepsis (9). The study group with early-onset sepsis showed 18 (62.1%) males, 11 (37.9%) females, mean gestational age (weeks) 34.28±4.7, mean body weight (gm) 2.1±0.8, mean Apgar score at 1 min. 6.7±1.8. 21 (72.4%) delivered by CS, 8 (27.6%) delivered by NVD. E. coli was the commonest organism identified in blood culture of septic neonates. Maternal anemia, PROM, and fever were significant risk factors for neonatal sepsis. Prematurity and low birth weights were among the most common neonatal risk factors. Respiratory manifestations were the commonest manifestations of neonatal sepsis in both groups. Treating maternal anemia during pregnancy will help to reduce the incidence of neonatal sepsis E. coli is still an important cause of early-onset neonatal sepsis. Blood cultures need to be done strictly before the start of the first dose of antibiotic.},
 year = {2016}
}

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