A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL-1 with detection limit of 0.013 and 0.75 μg mL-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.
| Published in | Modern Chemistry (Volume 5, Issue 6) |
| DOI | 10.11648/j.mc.20170506.12 |
| Page(s) | 93-100 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Extractive Colorimetry, Fexofenadine Hydrochloride, Irbesartan, Naphthol Blue Black, Pharmaceuticals
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APA Style
Safwan Ashour, Roula Bayram. (2017). Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Modern Chemistry, 5(6), 93-100. https://doi.org/10.11648/j.mc.20170506.12
ACS Style
Safwan Ashour; Roula Bayram. Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Mod. Chem. 2017, 5(6), 93-100. doi: 10.11648/j.mc.20170506.12
AMA Style
Safwan Ashour, Roula Bayram. Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals. Mod Chem. 2017;5(6):93-100. doi: 10.11648/j.mc.20170506.12
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Download@article{10.11648/j.mc.20170506.12,
author = {Safwan Ashour and Roula Bayram},
title = {Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals},
journal = {Modern Chemistry},
volume = {5},
number = {6},
pages = {93-100},
doi = {10.11648/j.mc.20170506.12},
url = {https://doi.org/10.11648/j.mc.20170506.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20170506.12},
abstract = {A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL-1 with detection limit of 0.013 and 0.75 μg mL-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.},
year = {2017}
}
TY - JOUR T1 - Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals AU - Safwan Ashour AU - Roula Bayram Y1 - 2017/11/28 PY - 2017 N1 - https://doi.org/10.11648/j.mc.20170506.12 DO - 10.11648/j.mc.20170506.12 T2 - Modern Chemistry JF - Modern Chemistry JO - Modern Chemistry SP - 93 EP - 100 PB - Science Publishing Group SN - 2329-180X UR - https://doi.org/10.11648/j.mc.20170506.12 AB - A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7–53.8 and 10–244 μg mL-1 with detection limit of 0.013 and 0.75 μg mL-1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision. VL - 5 IS - 6 ER -
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