Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences

Julian Ananiev; Mariana Penkova; Kiril Slaveykov; Georgi Tchernev

doi:doi:10.11648/j.sjcm.20140304.13

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Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences

Julian Ananiev, Mariana Penkova, Kiril Slaveykov, Georgi Tchernev

Published in Science Journal of Clinical Medicine (Volume 3, Issue 4)

Received: 18 June 2014 Accepted: 29 July 2014 Published: 10 August 2014

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Abstract

Dieulafoy's lesion (DL) is a rare of cases of acute upper GIT bleeding. We investigate the immunohistochemical expression of several endothelial markers in a patient with Dieulafoy’s lesion of the stomach, by comparing the results with data on the expression of these markers in other types of gastric pathology. The histological examination of the patient with Dieulafoy’s lesion showed small erosive defect covered with fibrin, under which there were several highly deformed and dilated blood vessels with different diameters. We found that the expression of EC markers CD31, CD34, vWF and VEGF in gastric blood vessels of DL is heterogeneous and there is some differences compared with endothelial markers expression in other gastric pathology.

Published in	Science Journal of Clinical Medicine (Volume 3, Issue 4)
DOI	10.11648/j.sjcm.20140304.13
Page(s)	70-74
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Gastric Blood Vessels, CD31, CD34, Von Willebrand Factor, VEGF

References

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[3]	Marangoni G, Cresswell AB, Faraj W, Shaikh H, Bowles MJ. An uncommon cause of life-threatening gastrointestinal bleeding: 2 synchronous Dieulafoy lesions. J Paediatr Surg 2009; 44: 441–3.
[4]	Muller AM, Hermanns MI, Skrzynski C, Nesslinger M, Muller KM, Kirppatrick J Expression of the endothelial markers PECAM-1, VWf and CD34 in vivo and in vitro. Exp Mol Pathol 2002a; 72:221–229.
[5]	Ogawa K, Oguchi M, Yamabe H, et al. Distribution of collagen type IV in soft tissue tumors: An immunohistochemical study. Cancer. 1986;58:269-277.
[6]	Weiss HJ. von Willebrand factor and platelet function. Ann NY Acad Sci, 1991; 614:125–137.
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[8]	Marelli-Berg FM, Clement M, Mauro C, Caligiuri G. An immunologist's guide to CD31 function in T-cells. J Cell Sci. 2013 Jun 1;126(Pt 11):2343-52.
[9]	Pusztaszeri MP, Seelentag W, Bosman FT. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem. 2006 Apr;54(4):385-95.
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[14]	Hudson N, Balsitis M, Everitt S, Hawkey CJ. Angiogenesis in gastric ulcers: impaired in patients taking non-steroidal anti-inflammatory drugs. Gut. 1995 Aug;37(2):191-4.

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APA Style

Julian Ananiev, Mariana Penkova, Kiril Slaveykov, Georgi Tchernev. (2014). Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences. Science Journal of Clinical Medicine, 3(4), 70-74. https://doi.org/10.11648/j.sjcm.20140304.13

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ACS Style

Julian Ananiev; Mariana Penkova; Kiril Slaveykov; Georgi Tchernev. Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences. Sci. J. Clin. Med. 2014, 3(4), 70-74. doi: 10.11648/j.sjcm.20140304.13

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AMA Style

Julian Ananiev, Mariana Penkova, Kiril Slaveykov, Georgi Tchernev. Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences. Sci J Clin Med. 2014;3(4):70-74. doi: 10.11648/j.sjcm.20140304.13

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@article{10.11648/j.sjcm.20140304.13,
  author = {Julian Ananiev and Mariana Penkova and Kiril Slaveykov and Georgi Tchernev},
  title = {Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences},
  journal = {Science Journal of Clinical Medicine},
  volume = {3},
  number = {4},
  pages = {70-74},
  doi = {10.11648/j.sjcm.20140304.13},
  url = {https://doi.org/10.11648/j.sjcm.20140304.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20140304.13},
  abstract = {Dieulafoy's lesion (DL) is a rare of cases of acute upper GIT bleeding. We investigate the immunohistochemical expression of several endothelial markers in a patient with Dieulafoy’s lesion of the stomach, by comparing the results with data on the expression of these markers in other types of gastric pathology. The histological examination of the patient with Dieulafoy’s lesion showed small erosive defect covered with fibrin, under which there were several highly deformed and dilated blood vessels with different diameters. We found that the expression of EC markers CD31, CD34, vWF and VEGF in gastric blood vessels of DL is heterogeneous and there is some differences compared with endothelial markers expression in other gastric pathology.},
 year = {2014}
}

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TY  - JOUR
T1  - Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences
AU  - Julian Ananiev
AU  - Mariana Penkova
AU  - Kiril Slaveykov
AU  - Georgi Tchernev
Y1  - 2014/08/10
PY  - 2014
N1  - https://doi.org/10.11648/j.sjcm.20140304.13
DO  - 10.11648/j.sjcm.20140304.13
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 70
EP  - 74
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20140304.13
AB  - Dieulafoy's lesion (DL) is a rare of cases of acute upper GIT bleeding. We investigate the immunohistochemical expression of several endothelial markers in a patient with Dieulafoy’s lesion of the stomach, by comparing the results with data on the expression of these markers in other types of gastric pathology. The histological examination of the patient with Dieulafoy’s lesion showed small erosive defect covered with fibrin, under which there were several highly deformed and dilated blood vessels with different diameters. We found that the expression of EC markers CD31, CD34, vWF and VEGF in gastric blood vessels of DL is heterogeneous and there is some differences compared with endothelial markers expression in other gastric pathology.
VL  - 3
IS  - 4
ER  -

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Author Information

Julian Ananiev

Department of General and Clinical Pathology and Forensic Medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Mariana Penkova

Department of Internal medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Kiril Slaveykov

Department of Ophthalmology and General medicine, Medical Faculty, Trakia Univercity, Stara Zagora, Bulgaria
Georgi Tchernev

Saint Kliment Ohridski University, Medical Faculty, University Hospital Lozenetz, Sofia, Bulgaria

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APA Style

Julian Ananiev, Mariana Penkova, Kiril Slaveykov, Georgi Tchernev. (2014). Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences. Science Journal of Clinical Medicine, 3(4), 70-74. https://doi.org/10.11648/j.sjcm.20140304.13

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ACS Style

Julian Ananiev; Mariana Penkova; Kiril Slaveykov; Georgi Tchernev. Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences. Sci. J. Clin. Med. 2014, 3(4), 70-74. doi: 10.11648/j.sjcm.20140304.13

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AMA Style

Julian Ananiev, Mariana Penkova, Kiril Slaveykov, Georgi Tchernev. Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences. Sci J Clin Med. 2014;3(4):70-74. doi: 10.11648/j.sjcm.20140304.13

Copy | Download

@article{10.11648/j.sjcm.20140304.13,
  author = {Julian Ananiev and Mariana Penkova and Kiril Slaveykov and Georgi Tchernev},
  title = {Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences},
  journal = {Science Journal of Clinical Medicine},
  volume = {3},
  number = {4},
  pages = {70-74},
  doi = {10.11648/j.sjcm.20140304.13},
  url = {https://doi.org/10.11648/j.sjcm.20140304.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20140304.13},
  abstract = {Dieulafoy's lesion (DL) is a rare of cases of acute upper GIT bleeding. We investigate the immunohistochemical expression of several endothelial markers in a patient with Dieulafoy’s lesion of the stomach, by comparing the results with data on the expression of these markers in other types of gastric pathology. The histological examination of the patient with Dieulafoy’s lesion showed small erosive defect covered with fibrin, under which there were several highly deformed and dilated blood vessels with different diameters. We found that the expression of EC markers CD31, CD34, vWF and VEGF in gastric blood vessels of DL is heterogeneous and there is some differences compared with endothelial markers expression in other gastric pathology.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences
AU  - Julian Ananiev
AU  - Mariana Penkova
AU  - Kiril Slaveykov
AU  - Georgi Tchernev
Y1  - 2014/08/10
PY  - 2014
N1  - https://doi.org/10.11648/j.sjcm.20140304.13
DO  - 10.11648/j.sjcm.20140304.13
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 70
EP  - 74
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20140304.13
AB  - Dieulafoy's lesion (DL) is a rare of cases of acute upper GIT bleeding. We investigate the immunohistochemical expression of several endothelial markers in a patient with Dieulafoy’s lesion of the stomach, by comparing the results with data on the expression of these markers in other types of gastric pathology. The histological examination of the patient with Dieulafoy’s lesion showed small erosive defect covered with fibrin, under which there were several highly deformed and dilated blood vessels with different diameters. We found that the expression of EC markers CD31, CD34, vWF and VEGF in gastric blood vessels of DL is heterogeneous and there is some differences compared with endothelial markers expression in other gastric pathology.
VL  - 3
IS  - 4
ER  -

Copy | Download